Synthesis of a Photoaffinity Analog of 3′-Azidothymidine, 5-Azido-3′-azido-2′,3′-dideoxyuridine.
نویسندگان
چکیده
منابع مشابه
Intracellular metabolism of CycloSaligenyl 3'-azido-2', 3'-dideoxythymidine monophosphate, a prodrug of 3'-azido-2', 3'-dideoxythymidine (zidovudine).
The administration of CycloSaligenyl 3'-azido-2',3'-dideoxythymidine monophosphate (CycloSal-AZTMP) to CEM cells resulted in a concentration- and time-dependent conversion to the 5'-monophosphate (AZTMP), 5'-diphosphate (AZTDP), and 5'-triphosphate (AZTTP) derivatives. High ratios of AZTMP/AZTTP were found in the CEM cell cultures treated with CycloSal-AZTMP. The intracellular T(1/2) of AZTTP i...
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In the title compound, C(14)H(19)N(3)O(4), the perhydro-pyran ring adopts a chair conformation. An intra-molecular C-H⋯O hydrogen bond generates an S(6) ring motif. In the crystal packing, mol-ecules are linked by O-H⋯O hydrogen bonds, forming infinite chains along [100].
متن کاملA swift and facile radiosynthesis of [alpha-32P]-3'-azido-3'-deoxythymidine 5'-triphosphate (AZT triphosphate).
Therapy with 3'-azido-3'-deoxythymidine (AZT, Zidovudine®) has become standard to improve both the quality of life and the survival of patients with acquired immunodeficiency syndrome (AIt)S) and AIDS-related complex (1). Isotopically labeled forms of AZT and its nucleotides are of particular importance in the continuing study of the mechanism of AZT action (2, 3) as well as its pharmacology (4...
متن کاملA Simple Method for the Preparation of Cis-(3-Azido-4-Styryl)-2-Azetidinone
The synthesis of the title compound is described. Deprotection of Cis(N-Trityl-3-azido-4-Styryl)-2-azetidinone to Cis-(3-azido-4-styryl)-2-azetidinone was found to be accelerated by the special salt effect under acidic condition
متن کاملCrystal structure of ammonium 3′-azido-3′-deoxythymidine-5′-aminocarbonylphosphonate hemihydrate: an anti-HIV agent
The asymmetric unit of the title compound, NH4 (+)·C11H14N6O7P(-)·0.5H2O, contains one 3'-azido-3'-de-oxy-thymidine-5'amino-carbonyl-phospho-nate (ACP-AZT) anion, half of an NH4 (+) cation lying on a twofold rotation axis and in another position, occupied with equal probabilities of 0.5, an NH4 (+) cation and a water mol-ecule. The amide group of the ACP-AZT anion is disordered (occupancy ratio...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.23.13660